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To determine the incidence, risk factors, and long-term sequelae of the purple glove syndrome )PGS) in hospital patients receiving IV phenytoin. A total of 152 patients received IV phenytoin and 9 (5.9%) developed PGS. PGS patients received a greater median initial dose of phenytoin, total 24 hour dose, and total number of doses (all p < 0.05). In addition, the median age of the PSG patients was older, their infusion was more often given for seizures, it was less likely to be administered in the operating room, and the length of their hospital stay was longer (all p < 0.05). One patient required surgical therapy, and all other patients resolved within 3 weeks with conservative management. PGS is not rare and elderly patients and individuals receiving large, multiple doses are particularly at risk. The iatrogenic complication may be preventable by substituting fosphenytoin for IV phenytoin. |
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adverse drug reaction
anticonvulsants,parenteral administration
anticonvulsants,untoward effects of
cost effectiveness
dilantin
dilantin,intravenous
fosphenytoin
iatrogenic neurologic disorders
old age,neurology of
purple glove syndrome
purple hands
risk factors
seizure
seizure,elderly
seizure,treatment of
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